( ISSN 2277 - 9809 (online) ISSN 2348 - 9359 (Print) ) New DOI : 10.32804/IRJMSH

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THE GREEN PROTOCOL AND BIOLOGICAL IMPORTANCE FOR THE SYNTHESIS OF SPIRO[INDOLINE-3,2’-THIAZOLIDINE]-3’-YL)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVE

    4 Author(s):  GAJANAND SHARMA , SATISH KUMAR NANDESHARIYA , ANIL K. SHARMA , RAJGOVIND SONI

Vol -  6, Issue- 3 ,         Page(s) : 33 - 46  (2015 ) DOI : https://doi.org/10.32804/IRJMSH

Abstract

Abstract:-The environmental friendly novel and facile route is develop for the synthesis of spiro-isatin- lenalidomide moiety have been synthesized from multi component reaction through a solid support reaction via two step procedure i.e. synthesis of compound (5a-e) from isatin (1a-e) reacted with lenalidomide (2) or another route synthesized compound (3a-e) reacted with thia glycolic acid (4) . Cyclization of these product (5a-e) with thia glycolic acid (4) in absolute ethanol have yielded Spiro[indoline-3,2’-thiazolidine]-3’-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivative . At last study of biological importance and pharmacological value of substituted product. It has been detected of substituted product by using elemental analysis, MS, IR, 1H NMR, 13C NMR.

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