HIV infection affects not only the people infected with HIV/AIDS but also affects the whole family including children. They are considered as vulnerable group in our society. PLHA are parents and caregivers who are facing many challenges to satisfy the needs of their children. HIV parents lose their support from the family members as well as the society.The socio-economic condition of the parent or caregivers increase the risk of illness and death among children. HIV/AIDS can also affect children’s normal childhood. Children from families living with HIV/AIDS often have to deal with psychosocial stress, an ill caregiver, reduced parenting capacity, a shift in family structure, financial deprivation, and stigma and discrimination. These challenges can lead to emotional and behavioral changes in children, such as depression and delinquency. Social studies in HIV, documented that the children from HIV affected families are more prone to social and psychological problems. In this paper, the researcher focus the problems and challenges faced by the HIV infected and affected children.