The scientific study of religion has thus far overlooked the study of beliefs and practices that are cantered on the notion of karma and its impact on Hinduism especially Jainism and Buddhism and its ethical causation across one or different lifetimes. Here, we outline a set of pertinent questions about karmic beliefs and practices ripe for research, namely (1) their cultural distribution around the world, (2) their structure and content, and (3) their psychological and cultural antecedents and consequence .The meaning of the term karma has undergone a curious evolution. The word is Sanskrit and means act, action, and deed. The theory or idea, which the term was originally used to refer to, is that conscious beings typically humans determine their own destinies through the quality of their acts: man is master of his fate. In popular use, however, the term has acquired a fatalistic ring, so that if one sighs, it’s my karma, the implication is that one is the helpless victim of destiny.