This article examines how India-US relations during the Cold War period, marked by confrontation and mistrust, ushered in mutual cooperation in various fields ranging from defence and security cooperation to the nuclear deal, and counter-terrorism initiatives to the “strategic partnership” between them. The article further argues that during the Cold War era, India’s relations were examined purely from the ideological perspective but after the end of the Cold War in 1990 and the disintegration of the Soviet Union in 1991, geopolitical equations changed. The article evaluates those factors which brought New Delhi and Washington closer to each other.It discusses how the two Cold War antagonists-India and America- became close strategic partners in defence, security, space, trade and investment fields. Also, it discusses how China has emerged as a crucial factor in the growing ties between New Delhi and Washington.